Formula of Lamivudine : C8H11N3O3S
Lamivudine is referred to as the potent nucleoside analog reverse transcriptase inhibitor which is used for curing the chronic hepatitis B. It also helps in improving the seroconversion of e-antigen positive hepatitis B and also helps in improving the histology staging of the liver. But long use of the lamivudine can cause the occurrence of the resistant hepatitis B virus mutant. But due to its tolerance level, it is more commonly used across. In the year 1989, Bernard Belleau and Nghe Nguyen-Ga at the Montreal-based IAF BioChem International, Inc. laboratories, invented the lamivudine. Earlier it was designed as the antiviral agent but its effectiveness in curing HIV was found out by Yung Chi Cheng at the Yale University. It is the analogue of the cytidine which can inhibit both the types-1&2 of HIV reverse transcriptase and the reverse transcriptase of hepatitis B. Before being made active, it is needed to be phosphorylated into the triphosphate form.
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